HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(Pyridin-4-yloxy)benzene-1-sulfonyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(4-Pyridinyloxy)benzenesulfonic acid | HCID 2760497 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(Pyridin-4-yloxy)benzene-1-sulfonyl chloride hydrochloride | HCID 2735257 | 100% |
Reaction Steps
Part C: A slurry of the sulfonic acid part B (420 g, 1.5 mol) in acetonitrile (2500 mL) and DMF (40 mL) was warmed to 75° C. under a nitrogen atmosphere and treated with thionyl chloride (243 mL, 3.3 mol) added dropwise over 3 hours. After stirring for one-half hour, the standard work-up procedure afforded 483 grams (100%) of the desired 4-[(pyrid-4-yl)oxy]benzenesulfonyl chloride hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06750228B1 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-0f1f81267f4547be9dac4edfd506adcd |
| Source note | uspto-grants-2004_06 |