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HRID353328

反应详情

EQUATION

反应方程式

HRID 353328 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：O=S(=O)(O)c1ccc(Oc2ccncc2)cc1
HCID2760497

4-[(Pyridin-4-yl)oxy]benzene-1-sulfonic acid

C11H9NO4S

PRODUCTS

生成物

1
结构：Cl.O=S(=O)(Cl)c1ccc(Oc2ccncc2)cc1
HCID2735257

4-[(Pyridin-4-yl)oxy]benzene-1-sulfonyl chloride--hydrogen chloride (1/1)

C11H9Cl2NO3S

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Part C: A slurry of the sulfonic acid part B (420 g, 1.5 mol) in acetonitrile (2500 mL) and DMF (40 mL) was warmed to 75° C. under a nitrogen atmosphere and treated with thionyl chloride (243 mL, 3.3 mol) added dropwise over 3 hours. After stirring for one-half hour, the standard work-up procedure afforded 483 grams (100%) of the desired 4-[(pyrid-4-yl)oxy]benzenesulfonyl chloride hydrochloride.

WORKUP

后处理

  1. additionadded dropwise over 3 hours