Water → Phthalylglycine aldehyde

HRID 353382Notes

Reaction equation

HRID 353382 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].O>C(Cl)Cl>[O:1]=[CH:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

Participants

4

Reactant 2

HCID 962WaterHCID 77499N-(2-Hydroxyethyl)phthalimide

Product 1

HCID 76201Phthalylglycine aldehydeYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The preparation from N-(2-hydroxyethyl)phthalimide was carried out as in example 2; cooling was carried out by means of tap water. Yield: 74%, m.p. 114° C. (from methylene chloride).

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-21e785f0d9014f708923c2354e9fed55
Source dataset
uspto-grants-2004_06
Patent number
US06750371B2

Reaction notes

Loading…