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Potassium Carbonate → HCID 22485267、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3,4-Dimethoxyphenol | HCID 16251 | — |
| 反応物 | 4-[[4-(3,4-dimethoxyphenoxy)phenyl] sulfonyl]-N-hydroxy-1-(2-propynyl)-4-piperidinecarboxamide, monohydrochloride | HCID 131723836 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 22485267 | HCID 22485267 | 90.9% |
反応手順
Part C: To a solution of the propargyl amine of part B (8 g, 22.63 mmol) and powdered K2CO3 (8.8 g, 56.6 mmol) in N,N-dimethylformamide (150 mL) was added 3,4-dimethoxyphenol (6.98 g, 45 mmol) at ambient temperature. The composition was heated to 90 degrees Celsius for 36 hours. The solution was concentrated under high vacuum and the residue was dissolved in ethyl acetate. The organic layer was washed with 1N NaOH, H2O and dried over MgSO4. Chromatography (on silica, ethyl acetate/hexane) provided phenoxy propargyl amine as light yellow gel (10 g, 90.9%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06750233B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-c4f247054abc48ff84edbe21d6b3c677 |
| 出典メモ | uspto-grants-2004_06 |