反应详情

Part C: To a solution of the propargyl amine of part B (8 g, 22.63 mmol) and powdered K2CO3 (8.8 g, 56.6 mmol) in N,N-dimethylformamide (150 mL) was added 3,4-dimethoxyphenol (6.98 g, 45 mmol) at ambient temperature. The composition was heated to 90 degrees Celsius for 36 hours. The solution was concentrated under high vacuum and the residue was dissolved in ethyl acetate. The organic layer was washed with 1N NaOH, H2O and dried over MgSO4. Chromatography (on silica, ethyl acetate/hexane) provided phenoxy propargyl amine as light yellow gel (10 g, 90.9%).

1. temperatureThe composition was heated to 90 degrees Celsius for 36 hours
2. concentrationThe solution was concentrated under high vacuum
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe organic layer was washed with 1N NaOH, H2O
5. dry with materialdried over MgSO4