Guanidine → HCID 178513081, compound

HRID 353445Notes

Reaction equation

HRID 353445 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][C:12](S(C)(=O)=O)=[CH:11][C:10]=3Cl)[N:7]=[CH:6][C:5]=2[C:20]([OH:22])=O)[CH2:3][CH2:2]1.[NH2:23][C:24]([NH2:26])=[NH:25]>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]4[C:10]=3[CH:4]=[CH:5][CH:6]=[N:7]4)[N:7]=[CH:6][C:5]=2[C:20]([NH:25][C:24]([NH2:26])=[NH:23])=[O:22])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 3520GuanidineHCID 222679905-cyclopropyl-1-(2-chloro-4-methanesulfonylphenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 178513081HCID 178513081, compound

Procedure

coupling said 5-cyclopropyl-1-(2-chloro-4-methanesulfonylphenyl)-1H-pyrazole-4-carboxylic acid with guanidine to form N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine.

Sources & evidence

ORD record
ord-f8263021edaf4610967742b9eb181064
Source dataset
uspto-grants-2004_06
Patent number
US06753334B2

Reaction notes

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