5-Chloro-2-nitroaniline → 5-Methoxy-2-nitroaniline

Temperatur

80 °C

To a solution of 5-chloro-2-nitroaniline (5.0 g) in dimethylformamide (25 ml) was added 24% sodium methoxide in methanol (11 ml) and the mixture was heated at 80° C. for 4 hours. At the end of this time, the reaction mixture was cooled to room temperature and partitioned between ethyl acetate and water. The extract was washed with 20% aqueous sodium chloride solution and insoluble material was filtered off. The filtrate was concentrated in vacuo to give the desired compound (4.8 g, yield 99%).

1. temperatureAt the end of this time, the reaction mixture was cooled to room temperature
2. custompartitioned between ethyl acetate and water
3. washThe extract was washed with 20% aqueous sodium chloride solution and insoluble material
4. filtrationwas filtered off
5. concentrationThe filtrate was concentrated in vacuo

ORD-Eintrag

ord-2160e88dcc6e46949596226c7eeb3e7e

Quelldatensatz

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06753347B2