p-Xylyl bromide → 2-[2-hydroxyethyl-[(4-methylphenyl)methyl]amino]ethanol

HRID 353526Notes

Reaction equation

HRID 353526 reaction equation
[NH:1]([CH2:5][CH2:6][OH:7])[CH2:2][CH2:3][OH:4].[CH3:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]Br)=[CH:11][CH:10]=1>>[OH:4][CH2:3][CH2:2][N:1]([CH2:8][C:9]1[CH:16]=[CH:15][C:12]([CH3:13])=[CH:11][CH:10]=1)[CH2:5][CH2:6][OH:7]

Participants

3

Reactant 2

HCID 7721p-Xylyl bromideHCID 8113Diethanolamine

Product 1

HCID 42192082-[2-hydroxyethyl-[(4-methylphenyl)methyl]amino]ethanol

Procedure

2-[(2-Hydroxy-ethyl)-(4-methyl-benzyl)-amino]-ethanol was prepared according to the general method as outlined in Example 1 (Step 4). Starting from diethanolamine (4.84 g, 46 mmol) and 4-methylbenzyl bromide (8.5 g, 46 mmol), 8.2 g of the product was isolated. Yield, (85%); white solid; MS: 210.1 (M+H)+.

Sources & evidence

ORD record
ord-442d97af64364a469057fcf950616fe1
Source dataset
uspto-grants-2004_06
Patent number
US06753337B2

Reaction notes

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