反应详情

To a solution of 4-hydroxybenzenesulfonate sodium salt (52.35 g, 0.225) in 1L of isopropanol and 225 mL of a 1.0N solution of sodium hydroxide was added 59.96 g (0.45 mol) of 1 bromo-2-butyne. The resulting mixture was heated to 70° for 15 h and then the isopropanol was removed by evaporation in vacuo. The resulting white precipitate was collected by filtrtation, washed with isopropanol and ether and dried in vacuo to give 45.08 g (81%) of the desired product as a white solid.

1. temperatureThe resulting mixture was heated to 70° for 15 h
2. customthe isopropanol was removed by evaporation in vacuo
3. customThe resulting white precipitate was collected by filtrtation
4. washwashed with isopropanol and ether
5. customdried in vacuo