HRID353614

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)NCCN)nc32)[C@H](O)[C@@H]1O

HCID11192424

未命名化合物

HCID21978291

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)NCCNC(=O)NCCN(C(C)C)C4CCCCC4)nc32)[C@H](O)[C@@H]1O

HCID10212690

未命名化合物

PROCEDURE

实验过程

Prepared from N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide (Preparation 10) and N-{2-[cyclohexyl(isopropyl)amino]ethyl}1H-imidazole-1-carboxamide (Preparation 29) by a similar method to Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c96e02a5228342dab8a30eb92a9f0735
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06753322B2
来源说明: uspto-grants-2004_06

反应 SMILES

[NH2:1][CH2:2][CH2:3][NH:4][C:5]([C:7]1[N:15]=[C:14]2[C:10]([N:11]=[CH:12][N:13]2[C@H:16]2[C@H:20]([OH:21])[C@H:19]([OH:22])[C@@H:18]([C:23]([NH:25][CH2:26][CH3:27])=[O:24])[O:17]2)=[C:9]([NH:28][CH2:29][CH:30]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:8]=1)=[O:6].[CH:43]1([N:49]([CH:60]([CH3:62])[CH3:61])[CH2:50][CH2:51][NH:52][C:53](N2C=CN=C2)=[O:54])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1>>[CH:43]1([N:49]([CH:60]([CH3:62])[CH3:61])[CH2:50][CH2:51][NH:52][C:53]([NH:1][CH2:2][CH2:3][NH:4][C:5]([C:7]2[N:15]=[C:14]3[C:10]([N:11]=[CH:12][N:13]3[C@H:16]3[C@H:20]([OH:21])[C@H:19]([OH:22])[C@@H:18]([C:23]([NH:25][CH2:26][CH3:27])=[O:24])[O:17]3)=[C:9]([NH:28][CH2:29][CH:30]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[N:8]=2)=[O:6])=[O:54])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1