N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide → N-(2-{[({2-[Cyclohexyl(isopropyl)amino]ethyl}amino)carbonyl]amino}ethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide	HCID 11192424	—
Reactant	HCID 21978291	HCID 21978291	—
Product	N-(2-{[({2-[Cyclohexyl(isopropyl)amino]ethyl}amino)carbonyl]amino}ethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide	HCID 10212690	—

Reaction Steps

Prepared from N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide (Preparation 10) and N-{2-[cyclohexyl(isopropyl)amino]ethyl}1H-imidazole-1-carboxamide (Preparation 29) by a similar method to Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06753322B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-c96e02a5228342dab8a30eb92a9f0735
Source note	uspto-grants-2004_06