Hydrochloric Acid → HCID 70404474, compound

HRID 35363Notes

Reaction equation

HRID 35363 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:16][CH2:15][CH2:14][C@@H:13]3[C@H:8]([O:9][CH2:10][CH2:11][NH:12]3)[C:6]=2[CH:7]=1.O1CCN[C@@H]2CCOC3C=CC=CC=3[C@@H:18]12.[ClH:32]>>[ClH:32].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:16][CH2:15][CH2:14][C@@H:13]3[C@H:8]([O:9][CH2:10][CH2:11][N:12]3[CH3:18])[C:6]=2[CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 13609762trans-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazineHCID 14256326HCID 14256326, compound

Product 1

HCID 70404474HCID 70404474, compound

Procedure

In a similar way, substituting trans-10-fluoro-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine for the trans-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine above and using hydrogen chloride instead of maleic acid, results in the formation of trans-10-fluoro-3,4,4a,5,6,11b-hexahydro-4-methyl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine hydrochloride having a mp. of 244°-245° C.

Sources & evidence

ORD record
ord-72aeb09876554aebaa614218f4d682d4
Source dataset
uspto-grants-1988_08
Patent number
US04766212

Reaction notes

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