HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(Dimethylamino)-1-phenyl-1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 1,3-Dioxolane | HCID 12586 | — |
| Product | 3-(Dimethylamino)-1-phenyl-1-propanone | HCID 77042 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
30.0 g of acetophenone are mixed with 24.5 g of dimethylamine hydrochloride and 74.1 g of 1,3-dioxolane, 2.5 g of concentrated hydrochloric acid are added, and the mixture is heated to exactly 90° C. and maintained at that temperature for 3.5 hours. Excess dioxolane is distilled off and the residue is cooled to 0° C. The resulting 3-dimethylamino-1-phenylpropan-1-one of formula
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06753451B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-b264f027321045e58b8d03c1d1db12ab |
| Source note | uspto-grants-2004_06 |