反应详情

温度

0 °C

30.0 g of acetophenone are mixed with 24.5 g of dimethylamine hydrochloride and 74.1 g of 1,3-dioxolane, 2.5 g of concentrated hydrochloric acid are added, and the mixture is heated to exactly 90° C. and maintained at that temperature for 3.5 hours. Excess dioxolane is distilled off and the residue is cooled to 0° C. The resulting 3-dimethylamino-1-phenylpropan-1-one of formula

1. additionare added
2. temperaturethe mixture is heated to exactly 90° C.
3. temperaturemaintained at that temperature for 3.5 hours
4. distillationExcess dioxolane is distilled off