反应详情

温度

30 °C

A mixture of methoxyacetic acid (3 ml; 0.04 moles) and methoxyacetyl chloride (3 ml; 0.03 moles) was kept under stirring at 30° C. for 2 hours. To this mixture carnitine chloride (4 g; 0.02 moles) which had been previously dried was added. The resulting mixture was brought to 40° C. and kept under stirring for seven days. The mixture was then taken up with acetonitrile and the unreacted carnitine chloride was filtered off. Upon addition of tert-butyl methyl ether an oil precipitated. The oil precipitation was repeated four times with acetonitrile/tert butyl methyl ether. The oil which finally separated was lyophilized. Four grams of methoxy acetyl carnitine chloride were thus obtained. Yield: 75%

1. additionwas added
2. customwas brought to 40° C.
3. stirringunder stirring for seven days
4. filtrationthe unreacted carnitine chloride was filtered off
5. additionUpon addition of tert-butyl methyl ether an oil
6. customprecipitated
7. customThe oil precipitation
8. customThe oil which finally separated