Hydrochloric Acid → [1-(4-Cyano-tetrahydro-pyran-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amine hydrochloride

HRID 353930Notes

Reaction equation

HRID 353930 reaction equation
[C:1]([C:3]1([NH:9][C:10]([CH:12]([NH:20]C(OC(C)(C)C)=O)[CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:11])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)#[N:2].[ClH:28]>O1CCOCC1>[ClH:28].[C:1]([C:3]1([NH:9][C:10]([CH:12]([NH2:20])[CH2:13][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[O:11])[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22260478t-Butoxycarboxylic acid [1-(4-cyano-tetrahydro-pyran-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide

Product 1

HCID 22063105[1-(4-Cyano-tetrahydro-pyran-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

t-Butoxycarboxylic acid [1-(4-cyano-tetrahydro-pyran-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide (1000 mg, 2.62 mmol) was dissolved in 15 mL of 4 M HCl in dioxane. The solution was stirred at ambient temperature for 1 hr. The volatiles were removed in vacuo and the resulting paste was triturated with 25 mL of diethyl ether to give a fine white solid that was collected by filtration and dried in vacuo. The product was used without further purification. benzamide.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe resulting paste was triturated with 25 mL of diethyl ether
  3. customto give a fine white solid
  4. filtrationthat was collected by filtration
  5. customdried in vacuo
  6. customThe product was used without further purification

Sources & evidence

ORD record
ord-720190502fcb4acabcf243c4683b078b
Source dataset
uspto-grants-2004_06
Patent number
US06756372B2

Reaction notes

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