HCID 22091412, compound → HCID 22091413, compound

HRID 353960Notes

Reaction equation

HRID 353960 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([C:39]#[N:40])([NH:12][C:13](=[O:38])[CH:14]([NH:22][C:23]([CH:25]2[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]2)=[O:24])[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]>Cl.O1CCOCC1>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][C:9]([C:39]#[N:40])([NH:12][C:13](=[O:38])[CH:14]([NH:22][C:23]([CH:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)=[O:24])[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 22091412HCID 22091412, compound

Product 1

HCID 22091413HCID 22091413, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The ester from (a) was dissolved in 10 mL of 4 N HCl in 1,4-dioxane at 0° C. for 1 hour. The solution was concentrated in vacuo and the salt neutralized by sodium bicarbonate solution and the product extracted with CH2Cl2. After concentration of the organic extract, the crude product was purified by reverse-phase HPLC to yield the desired product; MS, m/z 462=M+1.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. extractionthe product extracted with CH2Cl2
  3. customAfter concentration of the organic extract, the crude product was purified by reverse-phase HPLC

Sources & evidence

ORD record
ord-e2f4fe667aca4c7dba153a98e5ba1436
Source dataset
uspto-grants-2004_06
Patent number
US06756372B2

Reaction notes

Loading…