Potassium Cyanide → HCID 22063407, compound

Temperature

-78 °C

1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1.

1. customGaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves
2. additionwere added
3. customthe mixture transferred to a pressure tube
4. temperatureThe solution was heated for 30 min at 60° C
5. temperatureThe mixture was cooled to −78° C.
6. temperatureheated at 60° C. for 4 h
7. filtrationThe reaction mixture was filtered
8. customthe filtrate was evaporated
9. customThe crude residue was purified by flash chromatography

ORD record

ord-7892ccadfabf4e64ba1bf8cc905510a1

Source dataset

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06756372B2