Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Amlodipine | HCID 2162 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86591092 | HCID 86591092 | — |
Reaction Steps
In 100 ml of methanol was dissolved 20 g of para-toluenesulfonic acid. A solution of 40 g of the amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise to the methanol solution, followed by stirring at 23° C. for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06756390B2 |
|---|
| Source dataset | uspto-grants-2004_06 |
|---|
| ORD ID | ord-36a41431abcd4903844e824154a2115b |
|---|
| Source note | uspto-grants-2004_06 |
|---|
