Amlodipine → HCID 86591092, compound

HRID 353984Notes

Reaction equation

HRID 353984 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][CH2:13][O:14][C:15]([C:17]1[CH:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=2[Cl:29])[C:21]([C:30]([O:32][CH3:33])=[O:31])=[C:20]([CH3:34])[NH:19][C:18]=1[CH2:35][O:36][CH2:37][CH2:38][NH2:39])=[O:16]>CO>[CH3:12][CH2:13][O:14][C:15]([C:17]1[CH:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=2[Cl:29])[C:21]([C:30]([O:32][CH3:33])=[O:31])=[C:20]([CH3:34])[NH:19][C:18]=1[CH2:35][O:36][CH2:37][CH2:38][NH2:39])=[O:16].[C:1]1([CH3:11])[CH:2]=[CH:3][C:4]([S:7]([O-:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 2162AmlodipineHCID 6101p-Toluenesulfonic acid

Product 1

HCID 86591092HCID 86591092, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Conditions

Temperature
23 °C

Procedure

In 100 ml of methanol was dissolved 20 g of para-toluenesulfonic acid. A solution of 40 g of the amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise to the methanol solution, followed by stirring at 23° C. for 3 hours.

Sources & evidence

ORD record
ord-36a41431abcd4903844e824154a2115b
Source dataset
uspto-grants-2004_06
Patent number
US06756390B2

Reaction notes

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