Ethanol → HCID 23512602, compound

HRID 354004Notes

Reaction equation

HRID 354004 reaction equation
C([O:3][C:4]([C:6]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:10][N:9]=[C:8]([CH2:19][OH:20])[N:7]=1)=[O:5])C.C(O)C>O>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:11]1[C:6]([C:4]([OH:5])=[O:3])=[N:7][C:8]([CH2:19][OH:20])=[N:9][CH:10]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 54138457HCID 54138457, compound

Product 1

HCID 23512602HCID 23512602, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 3.40 g (11.6 mmol) (2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester in 15 ml ethanol 0.69 g (17.42 mmol) NaOH in 15 ml H2O was added and the mixture stirred for 1 hr. The pH of the solution was adjusted to 1 and the solid was filtered off to give after drying 2.80 g (91%) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid as a pale brown solid.

Workup

  1. filtrationthe solid was filtered off
  2. customto give
  3. dry with materialafter drying 2.80 g (91%) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid as a pale brown solid

Sources & evidence

ORD record
ord-930448be104040ca8a4abd8f7a34502d
Source dataset
uspto-grants-2004_06
Patent number
US06756380B1

Reaction notes

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