Ethanol → HCID 23512602, compound

Participants

Reaction Steps

To a solution of 3.40 g (11.6 mmol) (2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester in 15 ml ethanol 0.69 g (17.42 mmol) NaOH in 15 ml H2O was added and the mixture stirred for 1 hr. The pH of the solution was adjusted to 1 and the solid was filtered off to give after drying 2.80 g (91%) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid as a pale brown solid.

Provenance & Evidence