Chlorosulfonic acid → 2-Acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol

HRID 35401Notes

Reaction equation

HRID 35401 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:9]=[CH:8][C:7]=1[OH:16])(=[O:3])[CH3:2].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:9]=[C:8]([S:18]([Cl:17])(=[O:20])=[O:19])[C:7]=1[OH:16])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 13210348N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide

Product 1

HCID 132103492-Acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol

Procedure

15.5 g (0.059 mole) of 2-acetamidomethyl-4-(1,1-dimethylethyl)-phenol are introduced at room temperature into 100 ml of chlorosulfonic acid. Stirring is continued for a further 15 minutes and the solution is stirred into ice water. The precipitate is filtered off with suction and recrystallized from toluene.

Workup

  1. filtrationThe precipitate is filtered off with suction
  2. customrecrystallized from toluene

Sources & evidence

ORD record
ord-3b69f045a12647a1bf61c0c7bf75b4dc
Source dataset
uspto-grants-1988_08
Patent number
US04766241

Reaction notes

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