6-Methoxy-2-cyclohexylbenzo[b]thiophene → Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

HRID 354083Notes

Reaction equation

HRID 354083 reaction equation
[CH:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([O:16]C)[CH:14]=[CH:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:18]1([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:9]=3[C:8]=2[C:31]([C:30]2[CH:29]=[CH:28][C:27]([O:26][CH2:25][CH2:24][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:35][CH:34]=2)=[O:32])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 108794206-Methoxy-2-cyclohexylbenzo[b]thiopheneHCID 111190664-(2-(Piperidin-1-yl)ethoxy)benzoyl chloride

Product 1

HCID 9825662Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

Procedure

The product from Example 19, Step 2 and 4-(2-Piperidin-1-yl-ethoxy)-benzoyl chloride were coupled according to procedure C above and the methyl protecting group removed using etanethiol/aluminum trichloride to yield the title compound.

Workup

  1. customremoved

Sources & evidence

ORD record
ord-3dc8d845d7c64643bd07edb32d08d73c
Source dataset
uspto-grants-2004_06
Patent number
US06756388B1

Reaction notes

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