(1-Benzylpiperidin-2-yl)methanol → [4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(1-Benzylpiperidin-2-yl)methanol	HCID 2735486	—
Edukt	2-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene	HCID 9865197	—
Produkt	[4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone	HCID 23512907	36%

Reaktionsschritte

The product from Step 2 (600 mg) was coupled with (1-benzyl-piperidin-2-yl)-methanol (379 mg) as is Example 10, Step 3 to yield the title compound (320 mg) after silica gel chromatography with 10% ethyl acetate/hexanes to 20% ethyl acetate/hexanes as the gradient eluant.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06756388B1
Quelldatensatz	uspto-grants-2004_06
ORD ID	ord-9b2015e6bfd948daacd0faf5365a3720
Quellennotiz	uspto-grants-2004_06