反应详情

To a stirred solution of 3 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 5 mmol of triethylamine and 3 mmol of 5,10-dihydro-5-(4-aminobenzoyl)-4H-pyrazolo-[5,1-c][1,4]benzodiazepine. The mixture is stirred at room temperature for 5 hours and is then washed with water, NaHCO3, and brine. The organic layer is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel to give the desired product as a solid, m.p. 142°-146° C.

1. washis then washed with water, NaHCO3, and brine
2. dry with materialThe organic layer is dried with Na2SO4
3. filtrationfiltered
4. customevaporated in vacuo
5. customto give a solid which
6. customis purified by flash chromatography on silica gel