Hydroxide → 4-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

HRID 354105Notes

Reaction equation

HRID 354105 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][CH:4]([C:12]([O:14]CC)=[O:13])[CH2:3]1.[OH-]>C(O)C>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][CH:4]([C:12]([OH:14])=[O:13])[CH2:3]1

Participants

4

Reactant 2

HCID 961HydroxideHCID 12909077Ethyl 4-oxochromane-2-carboxylate

Product 1

HCID 98557084-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The carboxylic acid group of the compound of Example 2 (ethyl 4-oxochromane-2-carboxylate) was treated with a metallic hydroxide base in ethanol, and then the aqueous layer was treated with an acid to form the free acid, which was washed with water and then dried to yield 3 g of 4-oxo-chromane-2-carboxylic acid.

Workup

  1. additionthe aqueous layer was treated with an acid
  2. customto form the free acid, which
  3. washwas washed with water
  4. customdried

Sources & evidence

ORD record
ord-5196757bd2644a829bbc28bfa7a7188e
Source dataset
uspto-grants-2004_06
Patent number
US06756403B2

Reaction notes

Loading…