Sodium Hydroxide → HCID 136425810, compound

HRID 354200Notes

Reaction equation

HRID 354200 reaction equation
[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([C:12]3[CH:13]=[C:14]([NH:22][CH:23]([CH3:28])[C:24]([O:26]C)=[O:25])[CH:15]=[N:16][C:17]=3[O:18][CH2:19][CH2:20][CH3:21])=[N:6][C:5]=2[C:4]([CH2:29][CH2:30][CH3:31])=[N:3]1.[OH-].[Na+]>CO.O.Cl>[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([C:12]3[CH:13]=[C:14]([NH:22][C@H:23]([C:24]([OH:26])=[O:25])[CH3:28])[CH:15]=[N:16][C:17]=3[O:18][CH2:19][CH2:20][CH3:21])=[N:6][C:5]=2[C:4]([CH2:29][CH2:30][CH3:31])=[N:3]1

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 135730619HCID 135730619, compound

Product 1

HCID 136425810HCID 136425810, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

The title compound of Example 83 in methanol (5 mL) was treated with a solution of sodium hydroxide (64 mg, 1.6 mmol) in water (2 mL) and the reaction mixture stirred at room temperature for 14 h. After concentration of the reaction mixture in vacuo, water (5 mL) was added and the solution acidified with conc. hydrochloric acid (5 drops) to afford a white precipitate, which was removed by filtration, and dried in vacuo to give the title compound as an off-white solid (180 mg, 0.43 mmol).

Workup

  1. customto afford a white precipitate, which
  2. customwas removed by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-b2a7308b618440bbbd010b17bf6c7ab8
Source dataset
uspto-grants-2004_06
Patent number
US06756373B1

Reaction notes

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