HRID354215

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(COC(=O)n1cc[n+](C)c1)c1ccccc1[N+](=O)[O-].[Cl-]

HCID11232610

未命名化合物

结构：CC(C)(C)c1ccc(OCC(=O)Nc2nc3c(ncn3[C@H]3C[C@H](O)[C@@H](CO)O3)c(=O)[nH]2)cc1

HCID136116097

未命名化合物

PRODUCTS

生成物

结构：CC(COC(=O)O[C@H]1C[C@H](n2cnc3c(=O)[nH]c(NC(=O)COc4ccc(C(C)(C)C)cc4)nc32)O[C@@H]1CO)c1ccccc1[N+](=O)[O-]

HCID136388380

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

As described for 11 with N2-((4-tertbutylphenoxy)acetyl)-2′-deoxyguanosine (6) (5 g, 6.58 mmol) in 50 ml dichloromethane and 2 (2.57 g, 7.9 mmol) in 50 ml dichloromethane. Purification via flash chromatography (0-10% methanol in toluene/ethyl acetate (1:1) yielded 3.53 g (81%) of the title compound.

WORKUP

后处理

customPurification via flash chromatography (0-10% methanol in toluene/ethyl acetate (1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4170e30dda0e41519b70c8fa1b39dae0
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06756492B1
来源说明: uspto-grants-2004_06

反应 SMILES

[C:1]([C:5]1[CH:33]=[CH:32][C:8]([O:9][CH2:10][C:11]([NH:13][C:14]2[NH:15][C:16](=[O:31])[C:17]3[N:18]=[CH:19][N:20]([C:29]=3[N:30]=2)[C@@H:21]2[O:28][C@H:25]([CH2:26][OH:27])[C@@H:23]([OH:24])[CH2:22]2)=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl-].[N+:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[CH:44]([CH3:55])[CH2:45][O:46][C:47](N1C=C[N+](C)=C1)=[O:48])([O-:37])=[O:36]>ClCCl>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]([NH:13][C:14]2[NH:15][C:16](=[O:31])[C:17]3[N:18]=[CH:19][N:20]([C:29]=3[N:30]=2)[C@@H:21]2[O:28][C@H:25]([CH2:26][OH:27])[C@@H:23]([O:24][C:47]([O:46][CH2:45][CH:44]([C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=3[N+:35]([O-:37])=[O:36])[CH3:55])=[O:48])[CH2:22]2)=[O:12])=[CH:32][CH:33]=1)([CH3:4])([CH3:2])[CH3:3]