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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 354215Generated: October 27, 2026

N3-[2-(2-nitrophenyl)propoxycarbonyl]-N-methyl imidazolium chloride → HCID 136388380, compound

https://huagongshe.com/reaction/354215

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN3-[2-(2-nitrophenyl)propoxycarbonyl]-N-methyl imidazolium chlorideHCID 11232610—
Reactant2-(4-(tert-Butyl)phenoxy)-N-(9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamideHCID 136116097—
SolventDichloromethaneHCID 6344—
ProductHCID 136388380HCID 13638838081%

Reaction Steps

As described for 11 with N2-((4-tertbutylphenoxy)acetyl)-2′-deoxyguanosine (6) (5 g, 6.58 mmol) in 50 ml dichloromethane and 2 (2.57 g, 7.9 mmol) in 50 ml dichloromethane. Purification via flash chromatography (0-10% methanol in toluene/ethyl acetate (1:1) yielded 3.53 g (81%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06756492B1
Source datasetuspto-grants-2004_06
ORD IDord-4170e30dda0e41519b70c8fa1b39dae0
Source noteuspto-grants-2004_06