HCID 12993799, compound → HCID 12993800, compound

HRID 354235Notes

Reaction equation

HRID 354235 reaction equation
Cl[C:2]1[C:3]([S:20]([CH3:23])(=[O:22])=[O:21])=[C:4]([C:14]2[O:18][N:17]=[C:16]([CH3:19])[CH:15]=2)[C:5]([CH3:13])=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]>C(O)C>[CH3:13][C:5]1[C:4]([C:14]2[O:18][N:17]=[C:16]([CH3:19])[CH:15]=2)=[C:3]([S:20]([CH3:23])(=[O:21])=[O:22])[CH:2]=[CH:12][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

3

Reactant 1

HCID 12993799HCID 12993799, compound

Product 1

HCID 12993800HCID 12993800, compoundYield 103.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.30 g of ethyl 5-chloro-2-methyl-3-(3-methylisoxazol-5-yl)-4-methylsulfonylbenzoate was dissolved in 20 ml of ethanol. After the reaction system was purged by nitrogen, 0.02 g of 5% palladium-carbon was added. The system was purged by hydrogen. A rubber ball filled with hydrogen was attached and the solution was stirred at room temperature for 3 hours. The palladium-carbon was removed from the reaction solution by filtration. The solvent was distilled off under reduced pressure to give 0.28 g of the title compound as white crystals. Melting point: 83-86° C.

Workup

  1. customAfter the reaction system was purged by nitrogen, 0.02 g of 5% palladium-carbon
  2. additionwas added
  3. customThe system was purged by hydrogen
  4. additionA rubber ball filled with hydrogen
  5. customThe palladium-carbon was removed from the reaction solution by filtration
  6. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-dd6399e1580e46cea492b146c17ff83f
Source dataset
uspto-grants-2004_06
Patent number
US06756497B1

Reaction notes

Loading…