反应详情

1.1 g of 2-amino-5-mercapto-1,3,4-thiadiazole are dissolved in 15 ml of about 6N methanolic hydrochloric acid. The solution is treated with 3 g of 5,7-dihydro-2-[[(4-methoxy-3 -methyl-2-pyridyl)methyl]sulphinyl]-5,5,7,7 -tetramethylindeno[5,6-d]imidazol-6(1H )-one. stirred at room temperature and then concentrated by means of a water-jet pump until crystallization is complete. The 2-[[5-amino-1,3,4-thiadiazol-2 -yl)dithio]methyl]-1-(1,5,6,7 -tetrahydro-5,5,7,7-tetramethyl-6 -oxoindeno[5,6-d]imidazol-2-yl)pyridinium chloride hydrochloride obtained is filtered off and washed with cold methanol; it exhibits a melting point of 161° (decomposition).

1. concentrationconcentrated by means of a water-jet pump until crystallization