Hydrochloric Acid → HCID 20508351, compound

HRID 354550Notes

Reaction equation

HRID 354550 reaction equation
[F:1][CH:2]([F:9])[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[NH2:4].[C:10](Cl)(=[O:12])[CH3:11].Cl>[OH-].[Na+].O1CCOCC1>[F:1][CH:2]([F:9])[CH:3]([NH:4][C:10](=[O:12])[CH3:11])[CH2:5][C:6]([OH:8])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 13273327HCID 13273327, compound

Product 1

HCID 20508351HCID 20508351, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2 mmole of beta-difluoromethyl beta-alanine in 5 ml of 1 N sodium hydroxide at 0° C. are added simultaneously from two syringes 160 mg of acetyl chloride diluted in 1 ml of dioxane and 2 ml of 1 N sodium hydroxide. After 30 minutes at 0° C. the solution is acidified by the addition of 6 N hydrochloric acid, then extracted well with dichloromethane. The organic phase is dried and concentrated to afford 3-difluoromethyl-3-(1-oxo-ethylamino) propionic acid.

Workup

  1. extractionextracted well with dichloromethane
  2. customThe organic phase is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-14e0c993636b4027b54bdc5a80a8ffc5
Source dataset
uspto-grants-1983_03
Patent number
US04375477

Reaction notes

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