tert-Butoxy bis(dimethylamino)methane → HCID 54054919, compound

HRID 354555Notes

Reaction equation

HRID 354555 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])[CH2:10][CH2:9][CH2:8]2.[CH3:22][N:23]([CH:25](N(C)C)OC(C)(C)C)[CH3:24]>CN(C)C=O>[CH3:22][N:23]([CH:25]=[C:10]1[C:11]2[C:7](=[CH:6][C:5]([O:4][C:3]3[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:2]=3[F:1])=[C:13]([N+:14]([O-:16])=[O:15])[CH:12]=2)[CH2:8][CH2:9]1)[CH3:24]

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 12887070HCID 12887070, compound

Product 1

HCID 54054919HCID 54054919, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.58 g of 5-(2,4-difluorophenoxy)-6-nitroindan and 8.2 g of bis(dimethylamino)tert.-butoxymethane were stirred in 5 ml of dimethylformamide for 60 minutes at 140° C. Concentration under vacuum yielded crude 1-dimethylaminomethylene-5-(2,4-difluorophenoxy)-6-nitroindan.

Workup

  1. concentrationConcentration under vacuum

Sources & evidence

ORD record
ord-5229464af48244988d44a83a2876ba92
Source dataset
uspto-grants-1983_03
Patent number
US04375479

Reaction notes

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