反应详情

A solution of 14 g of 2,3,4-trimethylpyridine in 140 ml of methylene chloride is treated cautiously while cooling with ice with 21 g of m-chloroperbenzoic acid. The reaction mixture is boiled at reflux for 1 hour, then made basic with a saturated soda solution and subsequently extracted. The organic phase is dried and concentrated. The residue is purified on a silica gel column, the medium pressure flash chromatography method (solvent: methylene chloride/methanol [5:1 ) being used and the pressure being produced with nitrogen gas. The 2,3,4-trimethylpyridine N-oxide obtained is processed directly.

1. temperatureat reflux for 1 hour
2. extractionsubsequently extracted
3. customThe organic phase is dried
4. concentrationconcentrated
5. customThe residue is purified on a silica gel column
6. customthe pressure being produced with nitrogen gas