HCID 19841578, compound → Pyrimidine, 2-(1,1-dimethylethyl)-

HRID 354630Notes

Reaction equation

HRID 354630 reaction equation
NCCC[CH2:5][C:6]([CH3:11])([CH3:10])[C:7]([NH2:9])=O>[Pd].N1C=CC=CC=1>[C:6]([C:7]1[N:9]=[CH:5][CH:6]=[CH:7][N:9]=1)([CH3:5])([CH3:10])[CH3:11]

Participants

4

Reactant 1

HCID 19841578HCID 19841578, compound

Product 1

HCID 94597Pyrimidine, 2-(1,1-dimethylethyl)-

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1049PyridineSolvent

Procedure

A pyridine solution of 3-aminopropylpivalamide (approximately 35 percent by weight aminoamide) was fed continuously to a heated 1"×20" reactor maintained at 330° to 345° C. The reactor was packed with 50 g of 0.5 percent palladium on alumina. After removal of pyridine by distillation, the product, 2-t-butylpyrimidine was obtained, b.p. 160° to 163° C.

Workup

  1. temperaturea heated 1"×20" reactor
  2. temperaturemaintained at 330° to 345° C
  3. customAfter removal of pyridine
  4. distillationby distillation

Sources & evidence

ORD record
ord-7bca7ea3759d49cebee4d02b2af5cc2d
Source dataset
uspto-grants-1983_03
Patent number
US04376201

Reaction notes

Loading…