反应详情

温度

55 °C

A mixture of 6.8 g of the product of Step A, 41 ml of dioxane and 8.15 ml of 2 N sodium hydroxide was heated on a water bath at 55° C. for 2 hours and was then cooled. 9.5 ml of 2 N hydrochloric acid were added to obtain a pH of 2-3 and the dioxane was distilled. Crystallization was effected and water diluted the mixture under stirring. The recovered precipitate was vacuum filtered, rinsed with water, empasted with ether and dried to obtain 5.87 g of the anti isomer of 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetic acid melting at 240° C. (decomp.).

1. temperaturewas then cooled
2. customto obtain a pH of 2-3
3. distillationthe dioxane was distilled
4. customCrystallization
5. additionwater diluted the mixture
6. filtrationfiltered
7. washrinsed with water
8. customdried