反应详情

In 150 ml of ethanol is dissolved 14.0 g of the above ethyl 2-acetyl-2-chloro-3-(3,4-diethoxyphenyl)propionate, followed by addition of 3.5 g of anhydrous barium hydroxide. The mixture is stirred under ice cooling for 30 minutes, then poured into 300 g ice-40 ml 6N-HCl, and extracted with ether. The ethereal layer is washed with water, dried (over MgSO4) and distilled to remove the ether. The above procedure provides 12.0 g (97.6%) of ethyl 2-chloro-3-(3,4-diethoxyphenyl)propionate as oil.

1. extractionextracted with ether
2. washThe ethereal layer is washed with water
3. dry with materialdried (over MgSO4)
4. distillationdistilled
5. customto remove the ether