反应详情

In a mixture of 60 ml ethanol and 60 ml 1N-HCl is dissolved 5.0 g of the 5-(3,4-diethoxybenzyl)-2-iminothiazolidin-4-one prepared above and the solution is heated under reflux for 8 hours. The reaction solution is cooled, and water is added thereto. The aqueous mixture is subjected to extraction with chloroform to give 4.3 g (86.0%) of 5-(3,4-diethoxybenzyl)thiazolidine-2,4-dione as crystals. Recrystallization from ethyl acetate-n-hexane yields colorless prisms melting at 98°-99° C.

1. customprepared above and the solution
2. temperatureis heated
3. temperatureunder reflux for 8 hours
4. temperatureThe reaction solution is cooled
5. extractionThe aqueous mixture is subjected to extraction with chloroform