Phenyl isocyanate → N-Cyclohexyl-N'-phenylurea

HRID 354691Notes

Reaction equation

HRID 354691 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1C=CC=CC=1>[CH:1]1([NH:7][C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 7672Phenyl isocyanate

Product 1

HCID 13451N-Cyclohexyl-N'-phenylurea

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5.26 g (0.02 mole) of(2-methyl 1-phenyloxy 2-hydroxy propyl)-cyclohexylamine is dissolved in 300 ml of benzene. 2.38 g (0.02 mole) of phenylisocyanate were added. Slight heating was observed as well as the appearance of a solid. It was heated under reflux for 1 hour. After cooling, it was filtered and the product was recrystallized in ethanol. Melting point 164° C.

Workup

  1. temperatureSlight heating
  2. temperatureIt was heated
  3. temperatureunder reflux for 1 hour
  4. temperatureAfter cooling
  5. filtrationit was filtered
  6. customthe product was recrystallized in ethanol

Sources & evidence

ORD record
ord-1e01f692b3ff47e184ea12f2104473ac
Source dataset
uspto-grants-1983_03
Patent number
US04376783

Reaction notes

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