alpha-Fluoro-3-phenoxybenzylbromide → alpha-Fluoro-3-phenoxybenzyl alpha-isopropyl-(3,4-dichlorophenyl)acetate

HRID 354706Notes

Reaction equation

HRID 354706 reaction equation
[CH:1]([CH:4]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=1)[C:5]([OH:7])=[O:6])([CH3:3])[CH3:2].[F:16][CH:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:19]=1>>[CH:1]([CH:4]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=1)[C:5]([O:7][CH:17]([F:16])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:19]=1)=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 13194583alpha-Fluoro-3-phenoxybenzylbromideHCID 205073302-(3,4-Dichlorophenyl)-3-methylbutanoic acid

Product 1

HCID 53806714alpha-Fluoro-3-phenoxybenzyl alpha-isopropyl-(3,4-dichlorophenyl)acetate

Procedure

This compound was prepared from α-isopropyl-(3,4-dichlorophenyl)acetic acid and α-fluoro-3-phenoxybenzylbromide following the procedure described in Example 2 Method B. The product, a colourless oil, was characterised by pmr spectroscopy. Chemical shift δppm (solvent CDCl3): 0.76 (3H, d, J=6 Hz, CH3); 1.07 (3H, d of d, J=6 Hz and J=2 Hz, CH3); 2.33 (1H, m, --CH(CH3)2); 3.28 (1H, d, J=10 Hz, CH); 7.24 (1H, d of d, J=56 Hz and J=2 Hz, CHF) and about 7.33 (12H, m, aromatic protons).

Sources & evidence

ORD record
ord-0a48fc49b84045efa131482784824fcd
Source dataset
uspto-grants-1983_03
Patent number
US04376784

Reaction notes

Loading…