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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 354744Generated: October 27, 2026

5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-7-nitro-2H-1,4-benzodiazepin-2-one → 2-Amino-2'-(o-chlorobenzoyl)-2-methyl-4'-nitro-propionanilide

https://huagongshe.com/reaction/354744

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-7-nitro-2H-1,4-benzodiazepin-2-oneHCID 20506156—
Reactant5-(o-chlorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-oneHCID 20506168—
SolventMethylenechloride HexaneHCID 21226440—
Product2-Amino-2'-(o-chlorobenzoyl)-2-methyl-4'-nitro-propionanilideHCID 20506169—

Reaction Steps

From 76 g (0.21 mol) of 2-amino-2'-(o-chlorobenzoyl)-2-methyl-4'-nitro-propionanilide there is obtained, in analogy to the details in paragraph (b) of Example 1, 5-(o-chlorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one of melting point 242° (methylene chloride/n-hexane).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04377522
Source datasetuspto-grants-1983_03
ORD IDord-abeb06a1c8da4b4cb78b1e2936385103
Source noteuspto-grants-1983_03