HCID 20506172, compound → HCID 20506160, compound

HRID 354757Notes

Reaction equation

HRID 354757 reaction equation
ClC1C2C(C3C=CC=CC=3F)=NC(C)(C)C(=O)N(C)C=2C=CC=1NC(NCCO)=O.[Cl:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[C:38]1[C:44]2[CH:45]=[C:46]([N:49]=C=O)[CH:47]=[CH:48][C:43]=2[N:42]([CH2:52][CH2:53][OH:54])[C:41](=[O:55])[C:40]([CH3:57])([CH3:56])[N:39]=1>>[NH2:49][C:46]1[CH:47]=[CH:48][C:43]2[N:42]([CH2:52][CH2:53][OH:54])[C:41](=[O:55])[C:40]([CH3:56])([CH3:57])[N:39]=[C:38]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=3[Cl:31])[C:44]=2[CH:45]=1

Participants

3

Reactant 2

HCID 20506172HCID 20506172, compoundHCID 20506184HCID 20506184, compound

Product 1

HCID 20506160HCID 20506160, compound

Procedure

From 6.5 g (0.018 mol) of 7-amino-5-(o-chlorophenyl)-1,3-dihydro-1-(2-hydroxyethyl)-3,3-dimethyl-2H-1,4-benzodiazepin-2-one there is obtained, in analogy to the details in paragraph (b) of Example 4, via [5-(o-chlorophenyl)-2,3-dihydro-1-(2-hydroxyethyl)-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]isocyanate, 1,-[5-o-chlorophenyl)-2,3-dihydro-1-(2-hydroxyethyl)-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]-3-(2-hydroxyethyl)urea of melting point 175°-176° (ethanol/ethyl acetate).

Sources & evidence

ORD record
ord-3879f3a953784fcba99f780f260d5909
Source dataset
uspto-grants-1983_03
Patent number
US04377522

Reaction notes

Loading…