HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-(o-chlorophenyl)2,3-dihydro-1-isopropyl-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]-3-(2-hydroxyethyl)urea → 7-amino-5-(o-chlorophenyl)-1,3-dihydro-1-isopropyl-3,3-dimethyl-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-(o-chlorophenyl)2,3-dihydro-1-isopropyl-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]-3-(2-hydroxyethyl)urea | HCID 20506159 | — |
| Reactant | [5-(o-chlorophenyl)-2,3-dihydro-1-isopropyl-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]isocyanate | HCID 20506187 | — |
| Solvent | 1,2-Dichloroethane methylene chloride | HCID 22020333 | — |
| Product | 7-amino-5-(o-chlorophenyl)-1,3-dihydro-1-isopropyl-3,3-dimethyl-2H-1,4-benzodiazepin-2-one | HCID 20506147 | — |
Reaction Steps
From 4 g (0.011 mol) of 7-amino-5-(o-chlorophenyl)-1,3-dihydro-1-isopropyl-3,3-dimethyl-2H-1,4-benzodiazepin-2-one there is obtained, in analogy to the details in Example 4, via [5-(o-chlorophenyl)-2,3-dihydro-1-isopropyl-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]isocyanate, 1-[5-(o-chlorophenyl)2,3-dihydro-1-isopropyl-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]-3-(2-hydroxyethyl)urea of melting point 243°-244° (1,2-dichloroethane/methylene chloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377522 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-e576444c3eb949088d6602f5c8dc5003 |
| Source note | uspto-grants-1983_03 |