HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromopropane → 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | 5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-7-nitro-2H-1,4-benzodiazepin-2-one | HCID 20506156 | — |
| Reactant | HCID 20506198 | HCID 20506198 | — |
| Solvent | Diethylether hexane | HCID 21584099 | — |
| Product | 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one | HCID 20506164 | — |
Reaction Steps
From 32 g (0.088 mol) of 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one and propyl bromide there is obtained, in analogy to the details in paragraph (c) of Example 1, with a reaction period of 3 days, 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-1-propyl-2H-1,4-benzodiazepin-2-one of melting point 142°-143° (ether/n-hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377522 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-652ece06fe5540e2bfbd52db13cd4e66 |
| Source note | uspto-grants-1983_03 |