2-Methylpiperidine → HCID 12834695, compound

HRID 354781Notes

Reaction equation

HRID 354781 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH2:18][CH3:19])[C:8]2[CH:20]=[CH:21][CH:22]=[CH:23][C:7]1=2)=[O:5].[CH3:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][NH:26]1>C(O)(C)C>[ClH:1].[CH2:18]([N:9]1[C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:6]([C:4](=[O:5])[CH2:3][CH2:2][N:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH:25]2[CH3:24])[C:7]2[CH:23]=[CH:22][CH:21]=[CH:20][C:8]1=2)[CH3:19]

Participants

4

Reactant 2

HCID 79742-MethylpiperidineHCID 20506254HCID 20506254, compound

Product 1

HCID 12834695HCID 12834695, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

6.6 gm (0.02 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-10-ethyl-11H-dibenzo[b,e][1,4]diazepin-11-one (m.p. 133°-134° C.) and 5 gm (0.05 mol) of 2-methyl-piperidine were refluxed in 100 ml of isopropanol for 2 hours. The reaction mixture was evaporated in vacuo, the residue was dissolved in methylene chloride, and the solution was washed with water. After evaporation of the solvent, the residue was dissolved in hot acetone, and the calculated amount of hydrochloric acid was added.

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe residue was dissolved in methylene chloride
  3. washthe solution was washed with water
  4. customAfter evaporation of the solvent
  5. dissolutionthe residue was dissolved in hot acetone
  6. additionthe calculated amount of hydrochloric acid was added

Sources & evidence

ORD record
ord-71319a8230104ae5a9554e5d378e42ad
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

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