2-Methylpiperidine → HCID 12834705, compound

HRID 354782Notes

Reaction equation

HRID 354782 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:12](=[O:16])[CH2:13][CH2:14]Cl)[C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[C:8](=[O:21])[NH:7][C:6]=2[CH:22]=1.[CH3:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]1>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:12](=[O:16])[CH2:13][CH2:14][N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH:24]3[CH3:23])[C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[C:8](=[O:21])[NH:7][C:6]=2[CH:22]=1

Participants

4

Reactant 2

HCID 79742-MethylpiperidineHCID 13646312HCID 13646312, compound

Product 1

HCID 12834705HCID 12834705, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

11.5 gm (0.034 mol) of 8-chloro-5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one (m.p. 235°-237° C.) and 16.2 gm (0.16 mol) of 2-methyl-piperidine were refluxed in 100 ml of isopropanol for 1 hour. The reaction mixture was then evaporated in vacuo, the residue was dissolved in chloroform, the solution was washed with sodium hydroxide, and the organic solvent was distilled off in vacuo. The residue was recrystallized from xylene.

Workup

  1. customThe reaction mixture was then evaporated in vacuo
  2. dissolutionthe residue was dissolved in chloroform
  3. washthe solution was washed with sodium hydroxide
  4. distillationthe organic solvent was distilled off in vacuo
  5. customThe residue was recrystallized from xylene

Sources & evidence

ORD record
ord-3b01b40d0d8a4ee8a330cc7c0f4754df
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

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