2-Ethylpiperidine → HCID 12834699, compound

HRID 354783Notes

Reaction equation

HRID 354783 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH3:18])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]1=2)=[O:5].[CH2:23]([CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][NH:26]1)[CH3:24]>C(O)CC>[ClH:1].[CH2:23]([CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][N:26]1[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH3:18])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]1=2)=[O:5])[CH3:24]

Participants

4

Reactant 2

HCID 942052-EthylpiperidineHCID 13646314HCID 13646314, compound

Product 1

HCID 12834699HCID 12834699, compoundYield 58.8%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

8.5 gm (0.027 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one and 8.5 gm (0.075 mol) of 2-ethyl-piperidine were refluxed in 85 ml of n-propanol for 3 hours, and the reaction mixture was worked up as described in Example 10. After recrystallization from a mixture consisting of equal parts of dioxane and acetone, 6.8 gm of the hydrochloride were obtained.

Workup

  1. customAfter recrystallization from a mixture

Sources & evidence

ORD record
ord-8d5185d21c8b4899bacf6aa63c76e830
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

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