Nanofin → HCID 12834700, compound

HRID 354784Notes

Reaction equation

HRID 354784 reaction equation
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH3:18])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]1=2)=[O:5].[CH3:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH:26]([CH3:30])[NH:25]1>C(O)(C)C>[CH3:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH:26]([CH3:30])[N:25]1[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[N:9]([CH3:18])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]1=2)=[O:5]

Participants

4

Reactant 2

HCID 68843NanofinHCID 13646314HCID 13646314, compound

Product 1

HCID 12834700HCID 12834700, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

6.3 gm (0.02 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one and 8.4 (0.075 mol) of 2,6-dimethyl piperidine were refluxed in 100 ml of isopropanol for 6 hours. The reaction mixture was worked up as described in Example 13. After recrystallization from ethyl acetate by addition of a little ether, 4.2 gm (54% of theory) of the title compound were obtained.

Workup

  1. customAfter recrystallization from ethyl acetate
  2. additionby addition of a little ether, 4.2 gm (54% of theory) of the title compound
  3. customwere obtained

Sources & evidence

ORD record
ord-6ba47e99fb514177beda56f34a006f9e
Source dataset
uspto-grants-1983_03
Patent number
US04377576

Reaction notes

Loading…