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Morpholine → 5,10-Dihydro-5-[3-morpholino-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 12834682 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 5,10-Dihydro-5-[3-morpholino-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 12834708 | — |
反応手順
6.0 gm (0.02 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 10 gm (0.11 mol) of morpholine were refluxed in 200 ml of isopropanol for 2 hours. The solvent was distilled off, the residue was dissolved in methylene chloride, and the solution was washed with water. After distilling off the solvent, the residue was recrystallized from isopropanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04377576 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-567c63c4e9f6495c94be736fc85b4f6d |
| 出典メモ | uspto-grants-1983_03 |